Plantar warts, which are warts on the soles of the feet, present unique challenges precisely because of their location and the constant pressure they endure. The pressure from walking actually causes these warts to grow inward, creating a callus-like appearance and often causing significant pain. You're right that the location makes topical treatments difficult because they do tend to rub off, and the constant pressure can interfere with healing. Additionally, because these warts are pushed deeper into the skin by pressure, they often require more aggressive treatment than warts in other locations. When treating plantar warts, it's important to consider both the effectiveness of the treatment and the impact on mobility during healing. Some treatments require staying off your feet as much as possible during recovery, which can be challenging depending on your lifestyle and work situation. You'll want to discuss with a specialist what treatment options would be most effective for your specific situation while causing the least disruption to your daily activities.